Aging is a natural and inevitable phenomenon. In humans, aging is caused by a complicated interplay between hereditary and environmental factors. Several rare conditions exist in man that exhibit certain phenotypic characteristics associated with aging. [1, 2] Premature-ageing syndromes are a heterogeneous group of rare genetic disorders having features resembling that of accelerated ageing.[3,4] So far, more than 100 syndromes exhibiting early aging symptoms have been identified, with an approximate global prevalence of 1:50.000. Depending on the onset of symptoms, they can be divided into congenital, infantile, juvenile/adult, and adult forms.4 Progeroid syndromes are a wide range of rare systemic diseases, which share significant anomalies in the orofacial region.[1]
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