Women entrepreneur play a significant role in the economic and social development. Women empowerment is essential to the good family and wealthy nation. MSMEs are significant support to the women entrepreneur. It is also present in the labor-intensive industries of the traditional micro, Small Enterprise sector and in the services that support it. It is a worldwide phenomenon that Micro and Small Enterprises are an important part of a nation's economic and social development.Micro and Small Enterprises are increasingly a major force for national economic growth. The MSMEs has recorded the highest growth rate during the last decade in Andhra Pradesh. The increase in the female labor force participation in MSMEs business may also be attributable to improving economic incentives in employment and policies favoring the employment of women. Women are highly important contributors to the country’s economic and social development. Over the years Tribal women participation in the economy has very slowly increasingin Andhra Pradesh. Tribal women constitute 4.37 percent of the total population of Andhra Pradesh.The present paper is an attempt to highlight the“Tribal women entrepreneurship and empowerment through MSMEs in North Coastal Andhra districts in Andhra Pradesh.