Aim: Systemic medications that are widely used to treat different diseases have ocular adverse effects. The aim of this article is to generate evidence for physicians to monitor the outcome while using these medications. Methods: 38 published articles from various journal were selected and complete literature review was done. Salient information pertaining to the drug, dosage and side effects was accumulated and compiled. Results: 12 of the commonly used medications were identified and their side effects ranging from mild to vision threatening were noted. The adverse effects were highlighted and presented. Conclusion: While prescribing these group of drugs physicians must be aware of their ocular side effects, and have a preset plan to monitor them, and to consult an ophthalmologist in order to manage them accordingly.