Background: Scrub typhus is a major public health problem in Asia Pacific region and is endemic in many countries including India . Million of cases have been reported annually during monsoon and post monsoon period. This study aims to find a serum biomarker to predict the severity of disease.
Methods : Authors conducted a hospital based study in Department of Medicine in sub Himalayan regions in patients of scrub typhus from June 2017-2018.
Results: Forty seven (53.4%) out of 88 patients of severe scrub typhus had hyperuricemia (p<0.05).The patients with hyperuricemia had significant transaminitis (p=<0.001), raised serum creatinine (p=0.008), thrombocytopenia (p= 0.001) ) and among the patients who died 40% had hyperuricemia. Thus serum uric acid levels had significant co relation with the severity of the disease .
Conclusion: The patients of scrub typhus with raised serum uric acid levels are associated with increased disease severity and morbidity.
Impact Factor
2022: 6.012
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