Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. In Ayurveda, a similar condition is described as Kampavata, a Vataja Nanatmaja Vyadhi, referred to as Vepathu in Charaka Samhita and elaborated as an independent disease entity in Basavarajiyam. Since modern management of PD is largely symptomatic, effective Ayurvedic interventions are of clinical interest. Objective: To evaluate the therapeutic efficacy of Bilwadi Kala Basti in the management of Kampavata (Parkinson’s disease). Materials and Methods: A single-group interventional case series was conducted on 20 patients aged 40–70 years diagnosed with Parkinson’s disease. Patients were administered Kala Basti using Bilwadi Panchamoola Kashaya with Mamsa Rasa as Avapa Dravya, along with Anuvasana Basti using Murchita Tila Taila. Clinical assessment was performed before and after treatment using subjective parameters and the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: Significant improvement was observed in Kampa (47.92%), Sthambha (44.12%), Deha Bhramana (10.71%), and Ksheena Mati (14.29%). Walking time (20 feet) reduced by 34.55%, and Marie’s sign frequency decreased by 19.55%. Sleep quality assessed by the Athens Insomnia Scale showed a 68.23% improvement. UPDRS scores demonstrated improvement in Activities of Daily Living (49.04%), Motor Examination (39.13%), and total UPDRS score (42.12%), with an overall improvement of 45.36%. Conclusion:Bilwadi Kala Basti provided significant symptomatic and functional improvement in patients with Kampavata, highlighting its potential role in the integrative management of Parkinson’s disease.