Study on antidiarrhoeal potentials of mangifera indica tender fruits seed kernel (mitfsk)

Objective: Mangifera indica Tender Fruits Seed Kernel (MITFSK) is traditionally used for the treatment of gastrointestinal disorders like diarrhoea and dysentery. Traditionally peoples of Tamil Nadu and Andhra Pradesh uses whole young fruit in the name of avakai used in pickle preparation. To understand the traditional claim of this fruits young seed kernel, the present study was undertaken to screen antidiarrhoeal activity using animal models. Materials and Methods: Castrol oil induced diarrhoeal model was considered to study dirrhoeal faecal output, gastro enteropooling, gastrointestinal motility, haematological parameters and small intestinal NA+K+ATPase, Ca2+ATPase, Mg2+ATPase and Nitric oxide activity. Results: Results revealed that all the methods clearly evidenced the role of MITFSK on diarrhoeal control. This plant extracts not only control diarrhoea but also restore all the haematological parameters. This also scavenges nitric oxide in small intestinal tissues. Conclusion: This study concluded that MITFSK is one of the best alternative therapies for the treatment of diarrhoea without any side effects.