A study to assess the effectiveness of structure teaching programme on healthy lifestyle practices in prevention of peptic ulcer diseases among adolescents in selected colleges in Bangalore. A pre-experimental one group pre testpost test design was used to assess the knowledge of adolescents on healthy lifestyle practices in prevention of peptic ulcer diseases. Sample of the study comprise of adolescents in selected colleges, Bangalore. The pre-test score was inadequate (83%) and after STP Post test score was adequate (86%). There was a significant improvement obtained from structured teaching programme on knowledge regarding healthy lifestyle practices in prevention of peptic ulcer.