Antioxidants play a vital role in the prevention and treatment of various diseases. The main objective of the present study was to access the antioxidant potential of specifically yellow colored, mature Citrus limon peel extracts in relation to its pharmacological importance. The determination of antioxidant activity was done using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, Reducing power assay and Superoxide dismutase (SOD) scavenging assay using ascorbic acid as reference standard. Extraction of lemon peels was carried using solvents of different polarity which includes methanol, ethyl acetate, chloroform and petroleum ether. Antioxidant assays revealed the strong antioxidant potential of the peel extracts as their IC50 values was found comparable with the ascorbic acid standard. DPPH antioxidant assay revealed that highest free radical quenching capacity was found in ethyl acetate extract with IC50 value 115.63 μg/ml AAE. Highest quenching capability (SOD assay) of ethyl acetate peel extract was reported to be 100.80 μg/ml AAE along with highest reducing capacity followed by methanol peel extract. The results of preliminary quantitative estimation indicated the presence of appreciable amounts of antioxidants which suggests that lemon peels may be proposed as a therapeutic approach for drug development against diseases and its pharmaceutical efficacy can be further studied.
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