Aim: Evaluate the effect of Arnica Montana on doxorubicin-induced myocardial infarction in wistar albino rats.. Background: Myocardial infarction is a disorder of cardiac cells injury, whenever the muscle tissue is not receiving enough oxygen in at atleast one area, myocardial localized necrosis occurs. This occurs while the blood flow to such cardiac muscle is restricted. Material & methods: The myocardial infarction model was performed in animal by the administration of 2 mg/kg doxorubicin (DOX) via i.p route for 14 day, and the antagonistic effect of the herbal arecamontana was evaluate by the assessment of the antioxidant effect in animal blood serum. Results & discussion: Arnica montana have the efficacy to reduces the cardiac infraction, which is confirm by decreasing the oxidative markers such as SOD, TBARS, Catalase, CKMB, GSH and LDH level. Conclusion: The result shows Arnica montana have a significant effect against doxorubicin induced myocardial infarction. Thus the Arnica montana have the potential and reliable treatment option for myocardial infarction.
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2022: 6.012
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