Correlation between hba1c and atherogenic index in type 2 diabetic patients

Introduction: HbA1c is considered the “gold standard” of glycemic control during the 6-8 week period. The atherogenic index of plasma (AIP) is considered as a predictive marker for plasma atherogenicity. This study was aimed to find out association between fasting blood glucose (FBG), HbA1c and atherogenic index in type 2 diabetic patients.
Objectives
1. To find out the correlation between fasting plasma glucose and atherogenic index in type 2 diabetic patients.
2. To find out the correlation between HbA1c and atherogenic index in type 2 diabetic patients.
Methods: It is a prospective analytical study. 100 diagnosed type 2 diabetes mellitus patients were divided into two groups depending on their HbA1c levels;
Group I: Good Glycemic Control group having HbA1c < 7.0% (n= 50) and
Group II: Poor Glycemic Control group having HbA1c ≥ 7.0% (n= 50).
Fasting blood sample was used to measure FBG, HbA1C, TC, TG, LDL-C and HDL-C with standard tests. Atherogenic index was calculated by using formula = log (TG/HDL-C).
Results: In type 2 diabetes mellitus patients; mean FBG, mean HbA1c and mean atherogenic index values were significantly higher in those patients having poor glycemic control than in those patients having good glycemic control. Also, atherogenic index is positively correlated with FBG and HbA1C.
Conclusion: AIP, which can be easily calculated from lipid profile, may be utilized for screening diabetic patients to predict both dyslipidemia and glycemic control. So, diabetic patients should be educated about regular monitoring of lipid profiles. Also, HbA1c can be utilized for screening high risk diabetic patients for early diagnosis of dyslipidemia.