
Acantholytic or Adenoid squamous cell carcinoma is a rare variant of squamous cell carcinoma. Whenever it is reported at the head and neck region, the sites are always the Sun-exposed areas. Retromolar pad area of mandible is one of the rarest sites for acantholytic squamous cell carcinoma. It is also documented that, the prognosis of this variant inside oral cavity is very poor. In this case report, this unusual variant will be discussed at a rare site of the oral cavity.