Ossifying fibroma (OF) is a common benign fibro-osseous neoplasm of the jaws with progressive enlargement of the affected jaw causing significant cosmetic and functional disturbances. Complete surgical removal with safe margin is the recommended treatment for OF. It has a high recurrence rate. An understanding of the molecular mechanisms behind them will be more beneficial for application of targeted therapies in such lesions.
A plethora of stem-cells have been identified in a vast array of tumors, especially in malignancies for applying targeted therapy. But their role in benign tumors is not yet determined. Studies have shown that OF show more proliferative nature of stromal-cells. The aggressive growth may be attributed to mesenchymal-stem-cell population which mediates through enhanced TGF- β signaling in a SMAD-2/3 dependent manner. This contributes to OF phenotype characterized by suppressed bone formation and aggressive stromal tissue growth. Hence the study was planned to evaluate immune his to chemical expression of SMAD-2 in OF.
10 Paraffin embedded tissue sections of his to pathologically diagnosed cases of OF were immune his to chemically stained with SMAD-2 & its nuclear expression was evaluated.
Descriptive statistical analysis was applied. The significant positive expression of SMAD-2 in present study revealed the role of mesenchymal-stem-cells mediating through TGF-β signaling in OF.
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