Study on clinical prognosis of patients admitted with sepsis

We decided to undertake a study to determine prognostic profile of patients admitted with severe sepsis. A total number of 110 cases of sepsis admitted in the medical wards were studied. This prospective study was conducted with the hospital ethics committee approval and informed written consent. The commonest clinical feature among patients was altered blood pressure 84 (88.4%) followed by altered temperature 78 (82.1%), Altered sensorium 77 (81.8%) and breathlessness 77 (81.1%). Oliguria was seen in 60 (63.2%) patients. Tachycardia was seen in 60 (63.2%) patients and tachypnea was present in 52 (54.7%) cases. Hemodynamic and renal dysfunctions have been the most prevalent disorders, respiratory involvement and thrombocytopenia have gone down while coagulopathy has increased significantly. Mortality has decreased significantly. We have performed a multivariate analysis of the early prognostic factors. Type, origin, sepsis etiology, lactate and the presence of organ dysfunction -except for hyperbilirubinemia and hypotension- were the most important mortality factors. The prognosis of sepsis and septic shock remains poor. Although prognostic factors have been identified for some patients, groups have not yet been able to identify the immediate or long-term prognosis for the majority of these septic patients.