Studies on the micellar properties of anionic surfactant in the absence and presence of spironolactone at room temperature

Solubilization is a phenomenon of dissolving the solute into solvent to form homogeneous system. Solubilization of drug is one of the important parameter for the discovery of a drug. In the present paper, we studied the solubility enhancement of a poorly soluble drug i.e., spironolactone with sodium dodecyl sulphate (SDS). Also determine the variation in critical micellar concentration (CMC) of SDS in the presence of different weight-volume ratio solution of spironolactone at room temperature by surface tension and conductivity method. From the measurements, various physicochemical and surface properties Critical micellar concentration (CMC), thermodynamic parameters (ΔG°m, ΔH°m, ΔS°m) have been determined. The negative value of ΔG°m shows spontaneity of solubilization process.