An in silico approach to curtail the action of obesity proteins with phytoconstituents

Obesity is recently becoming a global health problem with alarming number of prevalence. The obesity itself is not defined as a disease but rather a disease process which can end up in various health problems. Most of the synthetic drugs used for obesity have side effects and hence, development of alternative agents are required. But its challenging as it act by multiple factors like genetic, hormonal, environmental and dietary. The present study attempts to curtail the action of proteins by docking with phytoconstituents. Three targeted proteins were subjected for the study and the proteins selected were Fat mass and obesity associated protein, Resistin, and Leptin. Ligands were phytoconstituents belonging to different classes seen in fruits, vegetables and were docked using autodock tool. The binding efficiency of the ligands with each receptors were compared with synthetic drug orlistat. Results obtained were comparable with synthetic drug with daidzein being the better among phytoconstituents. Moreover, hydrogen bond interactions made by quercetin, catechin with targeted proteins were more than the synthetic drug. As these constituents are clinically safer, future efforts can be taken to frame a diet choosing food items containing these constituents for obese patients which will help to curtail the proteins using different mechanisms.