Short term effect of non selective cyclooxygenase inhibitor as an adjunct for the treatment of periodontal disease

Aim: The purpose of this study was to evaluate a non selective COX-inhibitor derived from propionic acid, ibuprofen, as an adjunct for periodontal disease treatment. Materials and Methods: 30 patients with progressive periodontal disease entered this study in order to examine clinical effects of a non-steroidal anti-inflammatory drug - ibuprofen, used as an adjunct to non-surgical periodontal treatment. After scaling and root planning, patients were randomly assigned to either receive orally 200 mg of ibuprofen per day for one month (group B), or not receive the drug (group A). Results: The obtained results show that the mechanical periodontal treatment brought to resolution the gingival inflammation with both groups as displayed by clinical improvement in PD, PI and BOP. They also showed statistically similar values (p>0.05) of PD reduction on day 14 and on day 30. Conclusion: We may conclude that systemic ibuprofen had relatively minor influence on resolution of gingival inflammation in periodontal disease.