Role of mcp-1 in first time vs recurrent myocardial infarction

Objectives: This study was undertaken to explore the role of MCP-1 in acute myocardial infarction (MI).
Background: MI is followed by an inherent and extensive inflammatory reaction leading to a plethora of cytokines released by the injured myocardium regulating tissue repair and the subsequent host outcome. Monocyte Chemoattractant Protein (MCP)-1 , a CC chemokine is greatly expressed in atherosclerotic plaques and has an established fundamental role in initiation and progression of atherosclerosis.
Methods: This study was conducted in the Department of Biochemistry, Lady Hardinge Medical College & associated SSKH in collaboration with the Department of Cardiology, G B Pant Hospital, New Delhi. Patients of Myocardial Infarction (MI) presenting within 24 hours of the event were recruited in 2 groups group A consisted of 100 patients of MI who do not have a family history of MI and group B consisted of 100 patients of MI who had a family history of MI. Each of these groups was further divided into 2 subgroups - patients with first time MI and patients with recurrent MI .Blood samples were evaluated for serum MCP-1 by ELISA.
Results: Patients with recurrent MI had higher serum levels of MCP-1 compared to patients with first time MI (p= 0.064) .Serum MCP-1 was significantly raised (p=0.049) in MI with a positive family history of MI.
Conclusions: MCP-1 has a key role in atherosclerosis and may be an encouraging biomarker for risk prediction in patients with coronary artery disease.