Background: Postoperative period of laparotomy for perforation peritonitis is often complicated by liver dysfunction secondary to infection and cholestasis. Coagulopathy is generally the first indication of liver dysfunction. Thus we planned to evaluate coagulation abnormality in liver dysfunction related to postoperative period of perforation peritonitis. Methodology: 100 subjects being operated for perforation peritonitis were included in the study. Coagulation profile was estimated pre operative day and on day 2 of post-operative period. The subjects were followed up till death or discharge.
Results: Fifth and sixth decade was commonest age group and skewed male preponderance was seen. Incidence of deranged PT/INR was 14%. Higher weigh, decreased hospital stay, positive blood culture, deranged PT/INR were factors associated with death. PT/INR was found to be having significant predictive ability for mortality with 90.9 % sensitivity and 50% specificity.
Conclusion: Deranged PT/INR predicts bad prognostic significance in subject undergoing laparotomy for perforation peritonitis.
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