Background: Malaria is one of the most prevalent parasitic disease of global importance. Malaria imposes great socioeconomic burden on humanity and it accounts for 85% of Global infectious disease burden. Plasmodium also requires glucose as a source of energy. Parasitized erythrocytes increase their utilization of glucose as much as 100 times than that of uninfected normal erythrocytes. Material and methods: Blood samples of healthy individuals and Malaria infected patients were collected into 2 vials, 2 ml in EDTA and 3 ml vial without any anticoagulant. Plasma and serum glucose concentrations were analyzed from collected blood by GOD-POD method at the interval of 0, 1 and 2 hours. Results: Higher rate of glucose utilization, approximately double, was observed in patients suffering with malaria in serum and plasma both. In whole blood, concentration of blood glucose is decreased from 86.3 ± 18 mg/dl to 66 ± 15.8 mg/dl at the end of 2nd hours. Similarly significant decrease observed in glucose concentrations in separated serum also. At 0 hour, observed mean was 86.3 ± 18 mg/dl which was decreased to 69.2 ± 17.3 mg/dl at the end of 2 hours. The concentrations of blood glucose in control and study group were compared statistically, showed significant difference with P value was <0.001. Conclusion: It was concluded that utilization of glucose in malaria infection is much higher than normal individual. Increased consumption of blood glucose is due to glycolysis of RBC and added effect of parasite consuming glucose for their growth and development.
Impact Factor
2017: 6.614
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