Interactions of metal with nucleic acid studies: a short review

Nucleic acids (DNA and RNA) are actually salts (or structures) of iron ions from the chemical spectrum. Therefore, it is difficult, if not impossible, to distinguish the function of DNA and RNA in their function with the metals. This progress has been largely due to major advances in nucleic-acid technology. We can now decompose, process, and synthesize nucleic acids in the same sequence, just as we would with other chemical molecules that we are testing. In addition, these heavy metals disrupt metalloululatory proteins and thus disrupt genetic expression. We need to understand the function of natural metalloregulators in genes and we need to design new metal-related ligands, which, like proteins themselves, take heavy metals before their damage is done. This review explains the interaction of iron in the context of nucleic acid electrostatics, and then provides examples of iron sites in various types of DNA and RNA. It is also useful to study the interaction of nucleic acid compounds to provide scientific information regarding the manufacture and construction of iron ore.