Granular cell variant of ameloblastoma- a unique aggressive tumor

Ameloblastoma is the most significant epithelial odontogenic tumor of concern for the oral pathologist because of its high incidence among all odontogenic tumors and true neoplastic (infiltrative and recurrent) potential, combined with its diversity of histologic patterns. Six histopathologic subtypes of ameloblastoma are recognized, amongst which granular cell ameloblastomas are the most uncommon lesions accounting for about 3–5%. It appears to be aggressive in nature, with a marked propensity for recurrence and can show metastasis. It exhibits diverse microscopic patterns, which occur either independently or in combination with other patterns.

Hereby we are presenting a rare aggressive case of granular cell ameloblastoma in the left retromolar region of mandible affecting a 38-year old male.