T. Cordifolia is commonly known as Guduchi in India. Guduchi is one of the most important herbs of Ayurveda used as Rasayana (rejuvenator) having wide ranging of health benefits. The prevalence of obesity is increasing to epidemic proportions globally. Hypercholesterolemia is a major risk factor for the development and progression of atherosclerosis and related cardiovascular diseases. There is an urgent need for an effective understanding of hyperlipidemia and its management. The present study was aimed to evaluate the antihyperlipidemic effect of ethanolic extract of stem of T.cordifolia in diet induced hyperlipidemic rats. Hyperlipidemia was induced in rats by feeding cholesterol (400mg/kg b.w) on diet basis in coconut oil as vehicle orally throughout the experimental period and simultaneously, the treatment groups received T. cordifolia (100 and 200 mg/kg b.w.) orally for 15 days. Atorvastatin (1 mg/kg b.w.) was used as a standard antihyperlipidemic drug. Serum cholesterol, triglycerides, HDL and LDL were analyzed at the end of the experiment. The aorta part is extracted and subject to histopathological examination. Aqueous extract of T. cordifolia at 200 mg/kg b.w. dose significantly decreased the serum cholesterol, triglycerides and LDL level when compared to that of standard drug. Thus the study revealed that the ethanolic extract of T. cordifolia was found to be effectively controlling the hyperlipidemic conditions.
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