Efficacy of 0.25% sodium hypochlorite oral rinse in patients with chronic periodontitis: a randomized controlled trial

Author: 
Kranti Konuganti., Ashwini S and Apoorva Kumar

Background & Objectives: Periodontal therapy is aimed at the removal of pathogenic biofilms by mechanical therapy and its conversion to healthy microbiota by antimicrobial and antiseptic agents. The aim of present randomized controlled clinical trial was to determine the efficacy of 0.25% sodium hypochlorite twice weekly oral rinse in chronic periodontitis.

Materials and Methods: 40 patients suffering from chronic periodontitis were randomized into test and control group. Professional subgingival irrigation with 0.25% sodium hypochlorite (test group) and mineral water (control group) into periodontal pocket was done followed by oral rinsing twice a week for 3 months. At day 14, subgingival irrigation was repeated and oral hygiene instructions were reinforced. Clinical parameters including Gingival index, Plaque index, Papillary Bleeding Index, Probing depth and Clinical attachment level were recorded at baseline and 3 months. Data analysis was carried out using SPSS package (Ver 10.5).

Results: Test group showed significant improvements in PBI, PD reduction and CAL gain compared to baseline over a period of 3 months (p < 0.001). No significant differences were seen in values of any clinical parameter in the control group. Intergroup comparison showed highly statistically significant differences for PD and CAL at 3 months (p < 0.001).

Conclusion: Periodontal therapy can be profited from the adjunctive use of sodium hypochlorite subgingival irrigation and oral rinse. Further studies are needed with larger sample size to evaluate the long term benefits of sodium hypochlorite in the prevention and treatment of chronic periodontitis.

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