Purpose: The purpose of the study was to develop and evaluated emulgels for treatment of viral born disease wart.
Methods: The 23 factorial designs were used to prepare emulgels. The effect of three factors, concentration of turmeric oil, glycerol and tween-80 were selected. The Thuja oil was used as drug, carbopol-934P as gelling polymer, glycerol as humactant, tween-80 as surfactant and turmeric oil as permeation enhancer. The drug and excipients were mixed in mortar pestle. The prepared batches of emulgel were characterized for appearance, drug content uniformity, homogeneity, pH, skin irritation, spreadability, in-vitro drug release, scanning electron microscopy and antiviral activity on humans. The BIT-soft 1.12 was used to determine the kinetics of drug release.
Results: The emulgel batches showed the white and cream colored, homogenous mixture with no aggregates. The FTIR studies showed drug excipient compatibility. The pH of various batches of emulgel was 6.1-6.7 and formulations showed no skin irritation. The spreadability was found to be 3.5±0.11-4.3±0.12 g.cm/sec. The drug content was found to be 98.95-99.85%. The percentage drug release was found to be 57.65±0.15-68.65±0.62 up to 150 minutes. Batch-F was selected best on the basis of maximum drug release. In-vivo study on human volunteers showed the 1 mm inhibition of wart after 2 weeks of application. The kinetics of drug release showed Korsmeyer-Peppas equation as a best-fit model with r2 value 0.9971 and k value 1.4123 that indicates anomalous transport.
Conclusion: It was concluded from result that batch-F of emulgel was best to inhibit the wart.
Impact Factor
2022: 6.012
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